Multiscale Modeling of Neurological and Psychiatric Diseases

We use multiscale modeling to look at brain diseases, treated by neurology, psychiatry, neurosurgery, physiatry (rehab) and other specialties.  Particular focuses have been on stroke, epilepsy and schizophrenia.  We have also modeled Alzheimer disease, Parkinson disease, dystonia and others.  As one example, our recent studies of schizophrenia have emphasized the need for multiple scale analysis for evaluating the connections between molecular and synaptic alterations at the lower scales with the transmission of information leading to disruptions of thought at the higher scales.